Dimethyl Sulfoxide
Apexbio Technology LLC Bendamustine HCl 3543-75-7 10mM (in 1mL DMSO)
Bendamustine HCl (CAS 3543-75-7) is an alkylating agent that induces cytotoxicity primarily through DNA damage Mechanistically it disrupts the mitotic checkpoint by downregulating key regulators such as polo-like kinase 1 Aurora kinase A and cyclin B1 leading to mitotic failure and subsequent apoptosis In myeloma models bendamustine activates apoptosis signaling that involves ATM-mediated G2 cell cycle arrest cleavage of caspase-3 and mitochondrial apoptotic pathways It demonstrates dose-dependent antiproliferative activity in dexamethasone-sensitive (MM1 S IC50 119 8 M) and resistant (MM1 R IC50 138 M) multiple myeloma cell lines Bendamustine represents a useful research tool for studying DNA damage response and apoptosis in hematological malignancy contexts
Apexbio Technology LLC Azacyclonol 115-46-8 10mM (in 1mL DMSO)
Azacyclonol (CAS 115-46-8) chemically referred to as -pipradol is a small molecule utilized primarily in neuropharmacological research due to its antipsychotic properties Although the precise molecular mechanism remains incompletely defined Azacyclonol is understood to modulate central neurotransmitter systems influencing pathways associated with psychosis Studies have demonstrated its capacity to reduce hallucinations and mitigate psychotic symptoms positioning it as a valuable investigational tool in psychiatric research and therapeutic exploration of psychosis-related disorders
Apexbio Technology LLC Acetaminophen 103-90-2 10mM (in 1mL DMSO)
Acetaminophen (paracetamol) is a cyclooxygenase-2 (COX-2) inhibitor widely employed in biomedical studies for investigating analgesic and antipyretic mechanisms Its inhibition of COX-2 enzyme activity occurs with an IC50 of approximately 25 8 M Experimental use includes inducing cellular hepatotoxicity models where acetaminophen exposure triggers glutathione depletion impaired glutathione peroxidase activity and ferroptosis-mediated cell death This makes acetaminophen useful in examining oxidative stress hepatic cell injury and associated cellular response mechanisms in vitro and in animal studies Additionally acetaminophen-mediated toxicity is applicable in screening protective agents or evaluating ferroptosis inhibitors in pharmacological research
Apexbio Technology LLC MI-77301 (SAR405838) 1303607-60-4 10mM (in 1mL DMSO)
MI-77301 (SAR405838 CAS 1303607-60-4) is a selective antagonist targeting the murine double minute 2 (MDM2) protein an E3 ubiquitin ligase responsible for negatively regulating tumor-suppressor p53 via ubiquitination and degradation By inhibiting the MDM2-p53 interaction (Ki 0 88 nM) MI-77301 stabilizes p53 elevates protein levels of p53 p21 and MDM2 and induces apoptosis Preclinical studies demonstrate selective growth inhibition in tumor cell lines harboring wild-type p53 (e g SJSA-1 RS4 11 LNCaP HCT-116) and potent tumor regressions in corresponding xenograft mouse models highlighting its utility for mechanistic studies and cancer therapeutic research
Apexbio Technology LLC ANA 12 219766-25-3 10mM (in 1mL DMSO)
ANA 12 (CAS 219766-25-3) is a potent and selective antagonist of tropomyosin receptor kinase B (TrkB) the receptor for neurotrophins BDNF and NT-4/5 It binds non-competitively to extracellular sites on TrkB exhibiting IC50 values of 45 6 nM (high-affinity site) and 41 1 M (low-affinity site) ANA 12 inhibits BDNF-induced TrkB activation effectively blocking downstream signaling pathways including PLC- PI3K and MAPK In mouse models ANA 12 administration reduces endogenous brain TrkB activity and demonstrates antidepressant and anxiolytic properties supporting its use for researching psychiatric disorders and neuronal signaling
Apexbio Technology LLC YO-01027 (Dibenzazepine, DBZ) 209984-56-5 10mM (in 1mL DMSO)
YO-01027 (Dibenzazepine DBZ CAS 209984-56-5) is a potent inhibitor targeting -secretase a multimeric aspartyl protease involved in the proteolytic cleavage of type I integral membrane proteins notably amyloid precursor protein-like (APPL) proteins and Notch receptors YO-01027 interacts with the N-terminal regions of presenilin dose-dependently inhibiting cleavage of APPL and Notch proteins Research indicates that YO-01027 modulates cell differentiation by suppressing Notch signaling pathways influencing cellular transitions and mucin (MUC16) synthesis illustrating its utility in cell biology and therapeutic studies of Notch-related signaling processes
eMolecules 2168-93-6 | n-Butyl sulfoxide | Oakwood Chemicals | MFCD00002093 | 162.290 | C8H18OS | 96.000 | CCCCS(=O)CCCC | 25g | 480102057
n-Butyl sulfoxide | Oakwood Chemicals | 2168-93-6 | MFCD00002093 | 162.290 | C8H18OS | 96.000 | CCCCS(=O)CCCC | 25g | 480102057
Medchemexpress LLC Dimethyl sulfoxide | 67-68-5 | MFCD00002089 | 99.9% | 78.13 g/mol | C2H6OS | 5mL
Dimethyl sulfoxide cryoprotectant vitrification agent (DMSO cryoprotectant vitrification agent) is a biochemical reagent that can be used as a biological material or organic compound for life science related research[1] This product has been sterilized and has no endotoxin It can be used for long-term cell cryopreservation and will not affect the normal growth of cells
Medchemexpress LLC Dimethyl sulfoxide (GMP like) | 67-68-5 | MFCD00002089 | 100.0% | 78.13 g/mol | C2H6OS | 100mL
Dimethyl sulfoxide (DMSO) (GMP Like) is the GMP Like class Dimethyl sulfoxide (HY-Y0320C) Dimethyl sulfoxide is an aprotic solvent that can dissolve water-insoluble therapeutic and toxic agents Dimethyl sulfoxide has a strong affinity for water and has the ability to rapidly penetrate or enhance the penetration of other substances through biological membranes Dimethyl sulfoxide also has potential free radical scavenging and anticholinesterase effects and may affect coagulation activity Dimethyl sulfoxide also induces histamine release from mast cells but is thought to have low systemic toxicity[1]
Medchemexpress LLC Dimethyl sulfoxide | 67-68-5 | MFCD00002089 | 100.0% | 78.13 g/mol | C2H6OS | 10mL
Dimethyl sulfoxide (DMSO) meets analytical specification of Ch P is an aprotic solvent that dissolves polar and non-polar compounds including water-insoluble therapeutic and toxic agents Dimethyl sulfoxide (DMSO) has a strong affinity for water and can rapidly penetrate or enhance the penetration of other substances into biological membranes Dimethyl sulfoxide also has potential free radical scavenging and anticholinesterase effects and may affect coagulation activity Dimethyl sulfoxide also induces histamine release from mast cells but is thought to have low systemic toxicity Dimethyl sulfoxide also exhibits antifreeze and antibacterial properties[1][2][3] br/ MCE provides Dimethyl sulfoxide that complies with the inspection standards (Ch P) of Part 4 of the Chinese Pharmacopoeia (2020 Edition) Amicrobic low endotoxin can be used in various biochemical experiments such as drug dissolution
Apexbio Technology LLC SL-327 305350-87-2 10mM (in 1mL DMSO)
SL-327 (CAS 305350-87-2) is a selective inhibitor targeting MEK1 and MEK2 kinases exhibiting IC50 values of 0 18 M and 0 22 M respectively MEK1/2 mediate the phosphorylation and activation of extracellular signal-regulated kinases (ERK) crucial components of the MAPK/ERK signaling pathway SL-327 treatment lowers phosphorylated ERK levels and subsequent activation of transcription factors including CREB Elk-1 and c-Fos influencing gene expression linked to synaptic plasticity In animal models SL-327 modulates drug-induced behaviors and neuronal plasticity processes making it a relevant molecular tool to investigate MAPK/ERK signaling pathways in neuroscience research
Apexbio Technology LLC Silymarin 22888-70-6 10mM (in 1mL DMSO)
Silymarin (CAS 22888-70-6) is a naturally occurring flavonoid complex derived from the seeds of plants belonging to the Asteraceae family notably milk thistle (Silybum marianum) This phytochemical mixture exerts cellular antioxidant and anti-inflammatory activities primarily by inhibiting lipid peroxidation scavenging free radicals stabilizing cell membranes and modulating intracellular signaling pathways linked to oxidative stress response In biomedical research silymarin is extensively studied for hepatoprotective properties and its potential applications in investigating liver injury hepatotoxicity models and oxidative stress-mediated cellular damage The compound can be appropriately dissolved in solvents such as methanol ethanol acetone or ethyl acetate and requires storage under dry cool and sealed conditions
Apexbio Technology LLC Dynasore 304448-55-3 10mM (in 1mL DMSO)
Dynasore is a non-competitive inhibitor targeting dynamin family GTPases including dynamin1 dynamin2 and Drp1 with an IC50 of approximately 15 M Dynamin GTPases mediate membrane fission processes required for endocytosis and intracellular vesicle trafficking through catalyzing GTP hydrolysis Dynasore inhibits dynamin-mediated endocytic pathways by blocking GTPase activity thus preventing vesicle scission during endocytosis In biological research dynasore is frequently used to investigate dynamin-dependent endocytosis in cellular and neuronal models facilitating studies on synaptic vesicle recycling membrane trafficking and signaling dynamics